Diabetic foot refers to a foot complication that arise as a result of diabetes, primarily due to prolonged high blood sugar levels which impair blood flow and nerve function. Aim: This study aimed to evaluate the effect of health education program for patients suffering from diabetic foot at diabetic center in king Fahad hospital. Research design: A quasi-experimental research design was used in this study. Sample: Purposive sample include 140 patients with diabetic foot. Setting: It was conducted at diabetic center at king Fahad hospital, Saudia Arabia. Tool: Two tools, 1st tool: included four parts: 1st part: Demographic characteristics of patients, 2nd part: Medical history of patients, 3rd part: Patients' knowledge, and 4th part: Patients' reported practices about diabetic foot, 2nd tool: Observation checklist questionnaire included two parts: 1st part: Neurological foot assessment and 2nd part: Peripheral vascular assessment. Results: The study result revealed that, 5.3 % of studied patients had good total knowledge pre apply health education program, become 77.2 % of them had good total knowledge post apply health education program. While 90.5 % of studied patients had unsatisfactory with total reported practices pre apply health education program become 92.0 % of them had satisfactory total reported practices post apply health education program. Conclusion: The patients' knowledge, and reported practices about diabetic foot improved post apply health education program. Recommendations: Continuous an educational program for patients regarding diabetic foot care in another place.