Obesity is a chronic metabolic disease characterized by an excess of fat stores in the body.It is a main cause for many diseases and may lead to disability and death given that it affects not just adults but also children and adolescents.Therefore,this study investigated the effect of Chia seed (Salvia hispanica L.) and Psyllium Husks (Plantago ovata) on weight loss,serum glucose,lipid profile and liver function enzymes in Obese Rats.Chemical composition of chia seed and psyllium husks were determined.Serum glucose, lipid profile and liver function enzymes also were determined.Albino rats were divided into seven groups (G1:negative control (NC): fed on basal diet, (G2:positive control (PC): 6 Obese rats fed on a high fat diet (+ control),(G3): 6 Obese rats fed on a high-fat diet + ground chia seeds only for 15% of the meal,(G4): 6 Obese rats fed on a high-fat diet + ground psyllium husks for only 15% of the meal,(G5): 6 Obese rats fed on a high-fat diet +ground chia seeds by 7.5% +ground psyllium husks by 7.5% of the meal,(G6): 6 Obese rats fed on a high-fat diet + ground chia seeds by 3.75% + ground psyllium husks by 11.25% of the meal and(G7): 6 rats fed on a high-fat diet + ground chia seeds at a rate of 11.25% + ground psyllium husks at a rate of 3.75% of the meal.The statistical analysis results showed that the protein, fat, Fiber and Ash content in chia seeds was higher than psyllium husks(28.19, 31.51,29.663

and 6.338%) ,respectively.While,the carbohydrates content in psyllium husks were much higher than chia seeds (84.0).A significant increase at (p≤0.05) of Serum glucose,total-cholesterol,triglycerides, LDL-C, andALT were noticed, while HDL-C, andAST were decreased in (+control) compared with (-control).On other hands, G3, G4, G5, G6 and G7 obese treated rats reversed these results, also, G6 give the best results compared with G3,G5,G7 and (+ control) group, which that its results near to (-control) group.Inconclusion, chia seeds by 3.75% + ground psyllium husks by 11.25% were more effective in reducing weight,blood glucose,improving lipid profile,and liver function, and therefore may be able to improve public health