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384743

Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

Article

Last updated: 13 Jan 2025

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Abstract

Background: Alopecia areata (AA) is a persistent hair follicle inflammatory condition with T lymphocyte invasion. Interleukin-18 (IL-18) and inflammatory proteins such as NOD-like receptor family pyrin domain containing 3 (NLRP3) have been connected with several inflammatory and autoimmune skin conditions.
Objectives: To evaluate serum IL-18 and NLRP3 in patients with AA.
Materials and methods: This case-control study comprised 50 patients with AA and 50 normal, healthy persons of comparable age and sex as a control group. Severity of AA was evaluated using the SALT score. ELISA kits were used to determine serum IL-18 and NLRP3 levels.
Results: Serum IL-18 and NLRP3 levels were considerably greater in patients vs. controls (P= 0.01,

DOI

10.21608/bmfj.2024.315109.2176

Keywords

Interleukin 18, NLRP3, Alopecia Areata

Authors

First Name

Salma

Last Name

Al Yamani

MiddleName

AwadAllah

Affiliation

M.B.B.Ch, Faculty of Medicine, Al-Azhar University

Email

salmayamany90@gmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Al Refaei

MiddleName

Mohamed

Affiliation

Dermatology, Venereology and Andrology department, Faculty of Medicine – Benha University,Egypt

Email

basant.moaz@hotmail.com

City

-

Orcid

-

First Name

Eman

Last Name

Hassan

MiddleName

Mohamed

Affiliation

Dermatology, Venereology and Andrology department, Faculty of Medicine, Benha University,Egypt

Email

eman.hassan01@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Nehad

Last Name

Fouad

MiddleName

Ahmed

Affiliation

Microbiology and Immunology department, Faculty of Medicine, Benha University

Email

nihad.abdelwahed@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Karem

Last Name

khalil

MiddleName

Taha

Affiliation

DERMATOLOGY ANDROLOGY DEPARTMENT FACULTY OF MEDICINE BENHA UNIVERSITY EGYPT

Email

karem.khalil@fmed.bu.edu.eg

City

-

Orcid

0000-0001-9816-6575

Volume

42

Article Issue

1

Related Issue

52766

Issue Date

2025-01-01

Receive Date

2024-08-24

Publish Date

2025-01-01

Page Start

256

Page End

262

Print ISSN

1110-208X

Online ISSN

2357-0016

Article File

BMFJ_Volume 42_Issue 1_Pages 256-262.pdf

PDF . 843.1kB

Link

https://bmfj.journals.ekb.eg/article_384743.html

Detail API

http://journals.ekb.eg?_action=service&article_code=384743

Order

25

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Serum Interleukin 18 and NLRP3 in patients with Alopecia Areata

Details

Type

Article

Created At

13 Jan 2025