Background: Bipolar disorder is a serious condition with bouts of depression, mania or hypomania and there are different risk factors shared in recurrence of the bouts of the disease and we try to identify importance of each. This study aimed to identify various risk factors that precipitate early recurrence of bipolar episodes and detection of predictive role of each risk factor in recurrence of bipolar disorder. Methods: This Cross-sectional study included fifty patients diagnosed as having bipolar disorder. All studied cases were subjected to the following: semi-structured interview including, Clinical examination, SCID-I, presence or absence of risk factors of recurrence, and pilot study. Results: There was a highly statistically significant difference regarding occupation among the studied group of bipolar patients (P = 0.024). High statistically significant difference between marital status and bipolar disorder recurrence (P = 0.036). Regarding education there was a statistically significant difference as most of our cases were school students (P = 0. 037). Conclusion: We found strong prediction was revealed between relapse rates and age which was significant in age group ≥ 40 years and with male gender and occupational status mainly for retired, housewife and employee, sexual satisfaction, current medical comorbidity and positive compliances to medicines and greater associations were revealed for communication problems, premorbid mood swings, also inverted sleep rhythm, also strong prediction was revealed between divorced, postgraduate participants or only once psychiatric admission than multiple (≥3 times).