Background: Despite advances in surgical techniques and anesthesia management, postoperative pain remains an important issue. TAP block provides an excellent postoperative analgesia, decreases opioid requirement, and is conducive to favorable respiratory mechanics. This study aimed to compare between analgesic contribution of external oblique intercostal block versus general anesthesia alone in major abdominal surgeries (abdominal exploration, open cholecystectomy and nephrectomy). Methods: This randomized open label clinical trial was conducted on 46 patients in Benha university hospitals during the period of 10 months. Patients were randomly allocated in two equal groups group A included 23 patients underwent GA + EOI plane block and group B included 23 patients underwent GA only. Preoperative assessment including full History taking, clinical examination and routine laboratory investigations was performed. The design of trial and pain score was clarified for participants during the preoperative anesthesia visit. Results: Intraoperative fentanyl consumption was significantly lower in group A than group B (P