Introduction and importance: Situs Inversus Totalis (SIT), is a rare congenital disease in which the thoracic and abdominal organs are positioned in the sagittal plane in a way that is a mirror copy of the normal position. This placement of the organs is a mirror image of the normal position. Despite the fact that this condition does not have any influence on normal health or lifespan, its detection is essential for the treatment of a wide variety of disorders, especially those that need surgical intervention.
Case presentation: We report a 33-year-old female with situs inversus totals with symptomatic gall bladder stones (Mucocele of gall bladder). Radiographic modalities confirmed the diagnosis. The patient was managed by laparoscopic cholecystectomy (LC). The patient had a smooth postoperative course with an uneventful recovery.
Conclusion: LC is a challenging procedure in patients with SIT with aberrant anatomy, mirror image port sites, difficult ergonomics and hand-eye coordination, and longer operative time. It should be performed by an experienced laparoscopic surgeon.