Background: Acne vulgaris (AV) is a common chronic inflammatory dermatological illness that substantially affects quality of life, especially in adolescents and young adults. The primary topical retinoid utilized in the management of mild to moderate AV involves Adapalene (ADP). Benzoyl Peroxide (BPO) generates free oxygen, facilitating the breakdown of bacterial proteins and demonstrating bactericidal efficacy against P. acnes. The combined ADP 0.1%/BPO 2.5% gel was offered as a management for AV. It integrates anti-inflammatory, comedolytic, keratolytic, and antibacterial characteristics. Excimer light refers to a type of ultraviolet (UV) light produced by an excimer laser, which is a type of gas laser and induces apoptosis in keratinocytes and T lymphocytes. Objective: This study aimed to highlight the role of Excimer Light and Topical Adapalene/ BPO Gel in Treatment of AV. Methods: We searched Science Direct, Google Scholar, and PubMed for Excimer Light, Adapalene, Benzoyl Peroxide and Acne Vulgaris. All were searched through the period from May 2011 to May 2024. The writers also reviewed relevant literature references, although they only included the most recent or comprehensive study. Documents in languages other than English have been excluded due to lack of translation sources. Unpublished papers, oral presentations, conference abstracts, dissertations, and other works that were outside the scope of large-scale scientific studies were excluded. Conclusion: Combined excimer light and ADP/BPO or ADP/BPO alone could be utilised as effective therapy for AV.