remains significant, and contribute to increased morbidity and mortality in this population. Aim the of this study to assess the incidence of life threatening complication in patients with systemic lupus erythematosus Design: A descriptive observational prospective cohort study, sixteen adult patients SLE data. Sample and Setting: Purposive sample of (60) adult patients were admitted to the Main Assiut University Hospital's Medical Emergency Department and Intensive Care Unit at Assiut University, Egypt. Tools: Participants were evaluated with Systemic lupus Erythematosus disease activity index (SLEDAI) and life threatening complications assessment tool. Results The study cohort consisted predominantly of females (mean age: 25.27±6.96 years). The mean SLEDAI score was 5.33±2.93, indicating moderate disease activity. High dependency on ICU care was observed, with critical multi-system complications primarily affecting cardiovascular, renal, and respiratory systems.. Conclusions: Patients with SLE were at significant risk of developing life-threatening problems affecting numerous organ systems, including the cardiovascular, renal, and respiratory systems. Recommendations: Nurses should prioritize comprehensive assessment, patient education, and timely care coordination to prevent and manage life-threatening complications in patients with systemic lupus erythematosus.