The Metasomatite uranium deposit is one of the significant uranium deposit categories world- wide, associating structurally-deformed rocks affected by metasomatic processes in a post-magmatic stage. U-mineralizations recorded along the contact zones at Gabal (G.) Abu Hamr, as well as, G. Gattar represents the unique discovered examples of the metasomatite U-deposits type in Egypt. Alkaline hydrothermal solutions arose at both sites during the youngest Red Sea-Gulf of Suez rifting extensional force, which affected Egypt since the Tertiary time along a NE- SW direction. These solutions generated a metasomatic zone between the arfvedsonite granite and the metavolcanics at G.Abu Hamr, and between the younger granite and the Hammamat sedimentary rocks (HSR) at G. Gattar. The residual melts, loaded with radioactive elements, are structurally controlled in both localities along the NNE-SSW direction. Primary and secondary U- and Mo-mineralizations were detected at the metasomatic zone of G. Abu Hamr, while only secondary U-mineralisations were recorded at the metasomatic zone at G. Gattar. Despite the difference in rock types in both localities, the mode of occurrence and genesis for both uranium mineralizations at the contact zones are quite very similar.