Background: The psychological problems that parents of children with thalassemia typically face have a detrimental impact on all aspects of their quality of life as well as their coping mechanisms with their children. Aim of the study: This study aimed to assess the correlation between psychological problems, quality of life and coping strategies among parents of children with Thalassemia. A descriptive correlational research design used in this study. Setting: This study was conducted at the blood transfusion unit in the blood diseases department at Benha specialized children hospital, Qalyubia Governorate. A purposive sample of 100 parents of children with thalassemia chosen from the previous setting. Instruments: instrument (1): A structured Interviewing Questionnaire Sheet, instrument (11): Depression, anxiety and stress (DASS) scale, instrument (111): Quality of life scale and instrument (V): Brief COPE strategies scale. The research results revealed that more than half of the studied parents had moderate level of total psychological problems (depression, anxiety and stress), nearly two thirds of them had a low level of total quality of life and more than half of them had low level of total coping strategies. The study concluded that there was a highly statistically significant negative correlation between total DASS, total quality of life and total coping strategies scales. While there was a highly statistically significant positive correlation between total quality of life and total coping strategies scales among the studied parents. According to study findings researchers. Recommended application of psycho-educational nursing program for all parents of children with thalassemia to improve their quality of life and, consequently, their coping mechanisms and lessen psychological issues.