Background: The best way to handle gallbladder stones and common bile duct stones that are present simultaneously is up for dispute. The combination of endoscopic ERCP stone extraction and laparoscopic cholecystectomy has been the standard of care since the development of endoscopic and laparoscopic methods.
Objective: The current study aimed to evaluate single-stage ERCP/laparoscopic cholecystectomy (LC) and two-stage ERCP/LC in terms of imaging frequency,
length of anesthesia, mean operating time, length of stay, and expenditures.
Patients and methods: Between June 2020 and January 2023, this multicenter retrospective comparative analysis was carried out in Qena University Hospitals, South Valley University, Qena and Assiut University Hospitals, Assiut University, Assiut. 
Results: This research covered 220 participants. At ERCP, all patients had their bile ducts cleared. Regarding baseline variables such as age, sex, abdominal pain, preoperative liver function test, bilirubin, and alkaline phosphatase level, there is no difference between the two groups. The length of hospital stay varies significantly.
Conclusion: When compared with two separate procedures, single-session ERCP/LC has been safely and successfully utilized in some circumstances and is related to a shorter hospital stay, a reduced frequency of imaging, and better patient satisfaction.