Background: Unknown is the precise chemical make-up of the fibrillar substance. It is believed that it is secreted multifocally by the ciliary epithelium, iris pigment epithelium, and peripheral anterior lens epithelium. Pseudoexfoliation syndrome has been associated with ischemic heart disease (IHD), arterial hypertension(AH), and type 2 diabetes. Certain illnesses, such as pseudoexfoliation, may be more common in people with diabetes mellitus. Diabetic patients had a higher prevalence of PEX than people without diabetes, according to Psilas. 
Objectives: to determine the relationship between diabetes mellitus and pseudoexfoliation syndrome.
Patient and methods: The ophthalmology department at Qena University Hospital was the site of this study. The patients were divided into two groups.
Results: A PXF diagnosis was associated with a significantly higher probability of DM. In terms of Binary Logistic Regression, pseudoexfoliation and DM displayed a significant correlation.
Conclusion: There was a strong correlation between pseudoexfoliation syndrome and diabetes mellitus. Patients diagnosed with PXF are 4.6 times more likely to be diabetic than subjects with no PXF.