Background: Due to functional hyperandrogenism, hyperinsulinaemia, and concomitant insulin resistance, which result in androgen excess and increased free androgen availability, altered granulosa cell activities, and altered follicular development, obesity has an impact on fertility. One of the most prevalent reasons of infertility in women related to anovulation is PCOS. From youth to post-menopausal age.
Objectives: To assess clinical parameters, metabolic and hormonal as hirsutism and menstrual irregularities in PCOs patient based on their body mass index.
Patients and methods: This study was done on 100 PCOs patients attending the outpatient clinic of the Department of Obstetrics and Gynecology South Valley University hospital. The patients were divide into 4 groups: Group A = females with BMI <18.5         (N= 16), Group B= females with BMI (18.5-25) (N= 28), Group C= females with BMI (25-30) (N= 28) and Group D= females with BMI >30 (N= 28).
Results: Regarding mean age, there was no statistically significant difference between the four groups, however there was a statistical difference in the four groups' height and weight. Regarding hormonal profile, there was no statistically significant difference between the four groups (FSH, TSH, PRL and LH). Regarding the impact of BMI on lipid profile, there was a statistically significant difference between the four groups (specially on LDL level). With increasing body mass index, like in group D, it was seen that random blood sugar, HA1c, and HOMA rose. saw no discernible relationship between BMI and the prevalence of oligomenorrhea and acne in PCOS women.
Conclusion: In conclusion, the result of the present study showed that there is significant effect of BMI on metabolic parameters in PCOs patients so there is significant effect of BMI on insulin resistant which is increased by increasing BMI which lead to hyperandrogenism and increasing blood glucose level. As regard clinical state there is no significant effect on acne, hirshutism and menstrual irregularity.