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401184

Severe Bleeding in Preoperative Conditions: Emergent Interventions to Control Condition-An Updated Review

Article

Last updated: 13 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Background: Severe bleeding during preoperative and intraoperative conditions remains a major cause of morbidity and mortality. The risk of hemorrhage is heightened by factors such as trauma, anticoagulant therapies, and surgical complications. Effective preoperative management and timely interventions are crucial for controlling severe blood loss and minimizing the associated risks.
Aim: This review aims to provide an updated synthesis of interventions and strategies used to control severe bleeding in preoperative conditions, focusing on the mechanisms of hemorrhage, risk factors, and the management techniques employed to stabilize patients.
Methods: A comprehensive review of the existing literature was conducted, analyzing the underlying mechanisms of bleeding, including coagulopathy and the body's response to hemorrhagic shock. Clinical approaches such as fluid resuscitation, pharmaceutical interventions, and surgical techniques for managing severe bleeding were discussed.
Results: The review highlighted that hemorrhagic shock often occurs due to trauma-induced coagulopathy, shock, or the consumption of clotting factors. Fluid resuscitation strategies, including the use of crystalloids, colloids, and blood products, are essential in stabilizing patients. Additionally, medications such as inotropes and adrenergic agonists play a vital role in improving cardiac output and blood pressure. Effective interventions in managing hemorrhagic shock were found to rely heavily on rapid response, tailored treatments, and evidence-based guidelines.
Conclusion: Severe bleeding in preoperative conditions presents a complex challenge. Immediate intervention through appropriate fluid therapy, the use of pharmaceuticals, and surgical techniques are essential in controlling blood loss. The timely recognition and management of coagulopathy, hemorrhagic shock, and underlying health conditions are critical to improving patient outcomes and reducing mortality in these high-risk situations.

DOI

10.21608/ejchem.2024.346876.11031

Keywords

severe bleeding, hemorrhagic shock, Fluid resuscitation, anticoagulants, Coagulopathy, Trauma, surgical intervention

Authors

First Name

Laila Hassan

Last Name

Al Salman

MiddleName

-

Affiliation

First Riyadh Health Cluster, Ministry of Health, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Abdul Aziz Khaled

Last Name

Al-Zaaqi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Sultan Ibrahim Ahmed

Last Name

Almannaa

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Salhah Yahya

Last Name

Alneami

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Yahya Mahdi Abdullah

Last Name

Awaji

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Emad Souleman

Last Name

Ebani

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Alanoud

Last Name

Alharthi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ghadah

Last Name

Altamimi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Nada Emad

Last Name

Al Sahhaf

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Basel Hamid

Last Name

Almuabbadi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hazzaa

Last Name

Alanazi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Reem N

Last Name

Albishi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Shatha Ahmed

Last Name

Alaryani

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Nada Ahmad

Last Name

Alhejali

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Maryam Salem

Last Name

Algarni

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Khulood Abdu

Last Name

Hekoomi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Maha Mohammed

Last Name

Jafri

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Zohoor Mahamaud

Last Name

Samtah

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Haifa Abdulaziz

Last Name

Bin Nafesah

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Shadia Maashi

Last Name

Alanazi

MiddleName

-

Affiliation

King Saud Medical City, Saudi Arabia

Email

-

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-12-23

Publish Date

2024-12-01

Page Start

1,803

Page End

1,811

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1803-1811.pdf

PDF . 484.9kB

Link

https://ejchem.journals.ekb.eg/article_401184.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401184

Order

401,184

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Severe Bleeding in Preoperative Conditions: Emergent Interventions to Control Condition-An Updated Review

Details

Type

Article

Created At

13 Jan 2025