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401181

Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions

Article

Last updated: 13 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Background: Platelet hyperactivity has a central role in the process of thrombosis during important stages like injury, sepsis, and cardiovascular events. Platelets are required for hemostatic plug formation, but the activation of platelets can also result in formation of pathological thrombi and life threatening events.
Aim: The goal of the present research is to examine the metabolic background of platelet hyperactivity and its implication in thrombosis in severe medical conditions.
Methods: A literature review was performed and the findings based on the biochemical processes accounting for platelet activation and aggregation during trauma, sepsis and cardiovascular diseases have been reported.
Results: The review identified that inflammation, oxidative stress and endothelial dysfunction are main factors that influence the platelet activation and thereby enhancing the thrombus formation and corresponding risks of stroke, myocardial infarction and pulmonary embolism.
Conclusion: Hyperactivity of platelets is essential during thrombosis in critical conditions. Knowledge of such biochemical pathways displays practical approaches on how the thrombotic risks that are so characteristic of individual critically endangered can be controlled.

DOI

10.21608/ejchem.2024.345516.11007

Keywords

Hyperactivity, Thrombosis, Critical illness, activated platelets, Inflammation, Platelet, oxidant stress

Authors

First Name

Ebtsam

Last Name

Mudhhi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Maysa Abdulrahman

Last Name

Al-Enizi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ali Mohammed

Last Name

Albgami

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Yousef Abdullah Saad

Last Name

Alarifi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hasan Ali Hasan

Last Name

Aljaizani

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Fahad Musaad

Last Name

Alwatban

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Sultan Ibrahim Ahmed

Last Name

Amannaa

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Majed Abdulah

Last Name

Alnassar

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mansour

Last Name

Al Shehaiwin

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Fawaz Abdulrahman

Last Name

Altayash

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Fawaz Saeed

Last Name

Alghamdi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mohammed Hasan

Last Name

Aljizani

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ali Mousa

Last Name

Mhajri

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Hassan Arar

Last Name

Zaebi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Mohammad Ateh

Last Name

Almalke

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ali Yousef Ali

Last Name

Hattan

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Sultan Saleh

Last Name

Alrebde

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ali Jabir

Last Name

Khuwairi

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Yasser Bakheet Mohammed

Last Name

Aldousari

MiddleName

-

Affiliation

King Saud Medical City, Riyadh, Saudi Arabia

Email

-

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-12-18

Publish Date

2024-12-01

Page Start

1,787

Page End

1,793

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1787-1793.pdf

PDF . 448.9kB

Link

https://ejchem.journals.ekb.eg/article_401181.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401181

Order

401,181

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Platelet Hyperactivity and Thrombosis: Biochemical Mechanisms in Critical Conditions

Details

Type

Article

Created At

13 Jan 2025