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401165

The Role of Tumor Microenvironment in Cancer Progression: A Pathological Approach to Biomarker Discovery

Article

Last updated: 13 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

Background: The tumor microenvironment (TME) plays a crucial role in the progression of various cancers, influencing both tumor growth and therapeutic responses. Comprising multiple cellular components such as cancer-associated fibroblasts (CAFs), immune cells, blood vessels, and the extracellular matrix (ECM). Moreover, therapeutic interventions like chemotherapy and radiotherapy can further modify their composition, potentially affecting treatment outcomes.

Aim: This review aims to examine the role of the TME in cancer progression, focusing on its components and the potential of targeted imaging for therapeutic and diagnostic applications. It explores how understanding the TME's cellular heterogeneity and response to treatment could improve cancer management, particularly through molecular imaging.

Methods: We reviewed preclinical and clinical studies that investigated TME-targeted imaging agents, including radiotracers and biomarkers associated with CAFs, cancer stem cells (CSCs), ECM, and immune cells. Various imaging modalities, such as positron emission tomography (PET), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT), were explored for their potential in diagnosing and monitoring cancer progression.

Results: Studies identified specific biomarkers such as fibroblast activation protein (FAP) and collagen type I as key targets for imaging TME components. Radiotracers like [68Ga]Ga-FAPI-04 and [68Ga]Ga-FAPI-46 demonstrated improved diagnostic sensitivity and tumor-specific imaging compared to conventional markers like [18F]-FDG. These imaging agents enabled better visualization of TME-related factors.

Conclusion: Targeting the TME using advanced imaging techniques holds significant promise for enhancing cancer diagnosis, prognosis, and therapeutic monitoring. The integration of molecular imaging with TME biomarkers offers a path to more personalized and effective cancer treatments.

DOI

10.21608/ejchem.2024.342983.10950

Keywords

Tumor microenvironment, Cancer Progression, Molecular Imaging, biomarkers, Cancer-Associated Fibroblasts, imaging modalities, Extracellular matrix

Authors

First Name

Fehan

Last Name

Alhomidany

MiddleName

Falah

Affiliation

Comet General Hospital, Ministry of Health, Saudi Arabia

Email

falhomidany@moh.gov.sa

City

-

Orcid

-

First Name

Abdulqader

Last Name

Muthaffar

MiddleName

Ali Ahmed

Affiliation

General King Fahad Hospital Jeddah, Ministry of Health, Saudi Arabia

Email

amozaffer@gmail.com

City

-

Orcid

-

First Name

Zahra Hajji

Last Name

Bohassan

MiddleName

-

Affiliation

Community Laboratory In Al-Hassa, Ministry of Health, Saudi Arabia

Email

zhbohassan@moh.gov.sa

City

-

Orcid

-

First Name

Salman

Last Name

Muyidi

MiddleName

M.

Affiliation

Jazan Health Cluster, Ministry of Health, Saudi Arabia

Email

salmanmaidi1402@gmail.com

City

-

Orcid

-

First Name

Nossiba

Last Name

Arkoubi

MiddleName

Hussain

Affiliation

General King Fahad Hospital Jeddah, Ministry of Health, Saudi Arabia

Email

nosaarkoubi@gmail.com

City

-

Orcid

-

First Name

Afaf

Last Name

Alsulami

MiddleName

Wazen

Affiliation

General King Fahad Hospital Jeddah, Ministry of Health, Saudi Arabia

Email

afaf-wazin@hotmail.com

City

-

Orcid

-

First Name

Effat

Last Name

Kadi

MiddleName

Adnan

Affiliation

General King Fahad Hospital Jeddah, Ministry of Health, Saudi Arabia

Email

effat.qadi@gmail.com

City

-

Orcid

-

First Name

Yousef

Last Name

Aldawaa

MiddleName

Sami

Affiliation

Wadi Al-Dawasir General Hospital, Ministry of Health, Saudi Arabia

Email

sed20099@hotmail.com

City

-

Orcid

-

First Name

Mohammed Ibrahim

Last Name

Zuayr

MiddleName

-

Affiliation

King Fahad specialty hospital, Ministry of Health, Saudi Arabia

Email

mizuayr@moh.gov.sa

City

-

Orcid

-

First Name

Mohammad

Last Name

Al-Amari

MiddleName

Ghaleb

Affiliation

Health Center Alhjrah, Ministry of Health, Saudi Arabia

Email

medo4541@gmail.com

City

-

Orcid

-

First Name

Wejdan

Last Name

Alhazmi

MiddleName

Mohammed

Affiliation

Hospital branch in Jazan, Ministry of Health, Saudi Arabia

Email

wemalhazmi@moh.gov.sa

City

-

Orcid

-

First Name

Riyad

Last Name

Zaidan

MiddleName

Ibrahim Ali

Affiliation

Jazan Health Cluster Chest Diseases Hospital in Jazan, Ministry of Health, Saudi Arabia

Email

rzidan@moh.gov.sa

City

-

Orcid

-

First Name

Badria Abdulmajeed

Last Name

Almalki

MiddleName

Dakhilallah

Affiliation

Consultant - Medical Microbiology, Alyamama Hospital; , Ministry of Health, Saudi Arabia

Email

kk29337@gmal.com

City

-

Orcid

-

First Name

Sami

Last Name

Alharbi

MiddleName

Mohammed

Affiliation

Forensic Medical Services Center, Ministry of Health, Saudi Arabia

Email

smalharbi9@hotmail.com

City

-

Orcid

-

Volume

67

Article Issue

13

Related Issue

46555

Issue Date

2024-12-01

Receive Date

2024-12-09

Publish Date

2024-12-01

Page Start

1,713

Page End

1,724

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 13_Pages 1713-1724.pdf

PDF . 562.1kB

Link

https://ejchem.journals.ekb.eg/article_401165.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401165

Order

401,165

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

The Role of Tumor Microenvironment in Cancer Progression: A Pathological Approach to Biomarker Discovery

Details

Type

Article

Created At

13 Jan 2025