Dombeyawallichii(Lindl.) Benth.exBaill. is a plant that has been traditionally used in various cultures for its medicinal and therapeutic properties.The plant spreading in tropicalAsia and Africa. The goal of the present review the systematic characteristics,Ethnomedicinal uses, chemical profile, and biological activitiesData of D. wallichiiwere undertaken using the analytical inductive approach based on a review of the literature and identifying what was evaluated and collected in these studies and statistics electronic databases such as EThOS, ProQuest, OATD, Google Scholar, Medline, PubMed, Science Direct, SciFinder, and SCOPUS. Literature search revealed that D. wallichiiis used. Most studies of D. wallichiiextracts take notes that the species have anti-inflammatory, antimicrobial, and antioxidant capacity. The study concluded that the phytochemical analysis of Dombeyawallichii revealed a rich chemical profile, including flavonoids, phenolic acids, alkaloids, glycosides and saponins. These compounds have been shown to have antioxidant and anti-inflammatory activities, which may contribute to the therapeutic properties of the plant.The plant was also found to contain quercetin, kaempferol, gallic acid and ursolic acid, which have been shown to have anti-inflammatory activity. Plant extracts have also been shown to have antimicrobial activity against several microorganisms, including bacteria and fungi.