The current study was carried out to evaluate the effect of replacing yellow corn with dried orange pulp (DOP) at three various levels, 15, 30, and 45%, on body weight changes, blood biochemical parameters, and immunity status of cross-breeding Barahama & Zibo calves (experiment 1). Moreover, to determine digestibility, rumen fermentation, nitrogen balance, and blood criteria of Barki sheep (experiment 2). Four experimental rations (C, R15, R30, and R45) were prepared in total mixed ration (TMR) with a similar roughage: concentrate ratio of 30:70% (70% concentrate feed mixture (CFM) + 20% corn silage + 10% wheat straw) on DM basis. Animals in the control group received TMR without dried orange pulp (C). Calves on R15, R30, and R45 received TMR included 15, 30, and 45% of the dried orange pulp in part as a replacement of yellow corn grains. Animals in the two experiments received the same previous rations in four comparable groups. The obtained results showed that calves on R15 (15% dried orange pulp) recorded the highest values of final body weight (FBW), average daily gain (ADG), and total gain (TG), being 456 kg, 1.49 kg, and 89.3 kg, respectively. They were followed by C (453.8, 1.46, and 87.8 kg), R30 (444.6, 1.44, and 86.3 kg), and R45 (446.9, 1.42, and 85.4 kg), respectively, with no significant differences among experimental groups. DOP was more effective in increasing the daily profit percentage relative to control, with values of 19.40, 9.42, and 15.24% for R15, R30, and R45, respectively. Digestion coefficients of DM, CP, CF, and EE were not significantly affected by adding DOP. However, the digestibility of NFE increased (P= 0.02), being 71.46, 72.13, 71.98, and 71.95% for C, R15, R30, and R45, respectively. Nitrogen balance (NB) values were not significantly affected by dietary treatments, being 8.16, 8,00, 7.97, and 8.18 g/d for C, R15, R30, and R45, respectively. TDN did not differ significantly, being 65.74, 66.70, 66.00, and 65.98% in the same respective order. The DCP value followed the same pattern. The values of rumen pH were significantly (P=0.045) decreased by increased dried orange pulp levels at 2 hours post feeding, being 6.33, 6.19, 6.16, and 6.12 mg/dl for C, R15, R30, and R45, respectively. Total rumen VFA was significantly higher (P<0.01) at 2 hours post feeding for R30 and R45, being 14.66 and 14.87 meq/dl, respectively, than C and R15 rations. Rumen NH3-N in R45 was significantly higher (P=0.038) at 2 hours after feeding, being 18.52 than C, R15, and R30 (18.11, 18.30, and 18.37 mg/dl, respectively). All blood biochemicals, hematological, and immune parameters were not significantly affected by DOP. Generally, the partial replacement of yellow corn grains in the CFM formula with orange pulp that has been dried didn't adversely affect Barahama & Zibo calves' body weight changes as well as digestibility, nutritive value, and nitrogen balance of Barki sheep, without any adverse effect on liver and kidney functions, and immunity status. DOP had greater efficiency in increasing the daily profit margin in fattening calves' rations and can take place of yellow corn grains up to 45%.