The research expresses the developmental trend towards rationalizing and improving energy efficiency as one directions of Egypt's Vision 2030. The study specifically focuses on the energy efficiency and neutrality of hospitals, which are among the most important and energy-consuming sectors. This is achieved through an inductive study of the relationship between the guidelines for designing hospitals and green health facilities and the concept of energy-neutral hospitals, as one objectives of this guide, Which is characterized by the balance between produced and consumed energy using solar cells (photovoltaic), which are considered the primary technology for generating renewable energy in buildings. This is followed by a study of models of local hospitals that consider energy conservation and the analysis of energy efficiency and conservation strategies, as well as solar energy systems, and their application to a local hospital using a simulation program to identify the main opportunities and challenges facing the establishment of energy-neutral hospitals, especially in Egypt. The research concluded that solar cells can achieve energy efficiency in hospitals, and their efficiency increases by producing energy when installed at a 20-degree tilt on a horizontal surface. Energy production doubles when they are installed on horizontal surfaces at an appropriate tilt angle and southern facades. Thus, solar cells are considered one of the essential means to achieve an energy-neutral hospital according to sustainable future visions.