Beta
ManageSearchChatDiscover
402141

Agarose hydroxyapatite composite hydrogel for enamel surface biomimetic remineralization (an in-vitro study)

Article

Last updated: 07 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Dental Materials

Abstract

ABSTRACT
This study focused on developing a biomimetic agarose-hydroxyapatite (AG/HA) composite hydrogel and its evaluation for enamel repair efficacy. Sixty-four human molar slices were allocated into four groups: Control, Etched, AG hydrogel-treated, and AG/HA composite hydrogel-treated (n=8), with assessments at different intervals (4, 7, and 21 days). Enamel demineralization was induced using 37% phosphoric acid, followed by application of AG and AG/HA hydrogels. The remineralization outcomes were evaluated using energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Vickers microhardness testing, and scanning electron microscopy (SEM). Statistical analysis was performed by one-way ANOVA and Tukey post hoc test. The findings revealed that the AG/HA significantly enhanced the calcium-to-phosphate (Ca/P) ratio and restored enamel hardness and crystal microstructure to levels comparable to control group, unlike the AG, which exhibited limited reparative effects. As a conclusion, AG/HA biomimetic hydrogels are effective in achieving rapid and sustained remineralization of enamel, closely replicating natural enamel structure.

DOI

10.21608/edj.2024.332056.3250

Keywords

Keywords: Agarose hydrogels, Biomimetic enamel remineralization, enamel demineralization, Hydroxyapatite

Authors

First Name

Abeer

Last Name

El Manhaly

MiddleName

Mahmoud

Affiliation

Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University. Alexandria, Egypt

Email

abeer.elmanhaly@gmail.com

City

-

Orcid

0009-0008-9001-3644

First Name

Abdel

Last Name

El Demerdash

MiddleName

Ghaffar Magraby

Affiliation

Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University. Alexandria, Egypt

Email

eldemerd@yahoo.com.uk

City

-

Orcid

0009-0006-5968-6440

First Name

Wagih

Last Name

Sadik

MiddleName

Abdel Alim

Affiliation

Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University. Alexandria, Egypt

Email

wagih_sadik@yahoo.com

City

-

Orcid

0009-0005-4503-4348

First Name

Sherif

Last Name

Kandil

MiddleName

Hussein

Affiliation

Department of Materials Science, Institute of Graduate Studies and Research, Alexandria University. Alexandria, Egypt

Email

s.kandil@usa.net

City

-

Orcid

0000-0003-2249-0808

First Name

Seham

Last Name

Hanafy

MiddleName

Ahmed

Affiliation

Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

sehamahelmy@gmail.com

City

-

Orcid

0009-0008-0790-4957

First Name

Dawlat

Last Name

Mostafa

MiddleName

-

Affiliation

Dental Biomaterials Department, College of Dentistry, The Arab Academy for Science and Technology and Maritime Transport (AASTMT), El-Alamein, Egypt.

Email

dawlatmostafa@aast.edu

City

Alexandria

Orcid

0000-0001-5454-4271

Volume

71

Article Issue

1

Related Issue

52688

Issue Date

2025-01-01

Receive Date

2024-11-02

Publish Date

2025-01-01

Page Start

631

Page End

643

Print ISSN

0070-9484

Online ISSN

2090-2360

Article File

EDJ_Volume 71_Issue 1_Pages 631-643.pdf

PDF . 1.7MB

Link

https://edj.journals.ekb.eg/article_402141.html

Detail API

http://journals.ekb.eg?_action=service&article_code=402141

Order

402,141

Type

Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

Agarose hydroxyapatite composite hydrogel for enamel surface biomimetic remineralization (an in-vitro study)

Details

Type

Article

Created At

07 Jan 2025