Background: SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) a novel coronavirus causing COVID-19 was identified in December 2019, The virus spread around the whole world in a short time and World Health Organization (WHO) declared the pandemic status by 11 March 2020. Aim and objectives: to investigate echocardiographic abnormalities in pediatric patients with COVID-19. Also, the study aims to correlate the clinical and laboratory data with echocardiographic findings. Subjects and methods: this retrospective study was conducted in Pediatric Department and PICU of Minia Insurance Hospital, Minia, Egypt. The study included 60 children divided into 3 groups; pneumonia, MIS-C and control; each had 20 children. The duration of the study ranged from 6-12 months. Results: there was a statistically significant difference between the studied groups regarding Presentation distribution, Echocardiographic parameters except in septal mitral e՛ and Lateral/septal e՛ ratio. There was no statistically significant difference between the studied groups regarding Demographic characteristics, Comorbidities distribution and Clinical course except in Myocarditis. Conclusion: the most common echocardiographic findings in MIS-C patients is right ventricular dysfunction. However, mid- and long-term follow-up studies are needed for both coronary artery involvement and left ventricular diastolic dysfunction in MIS-C patients.