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Regenerative potential of Concentrated Growth Factor (CGF) Membrane in an Induced Bone Defect Model in Rabbits: A Light Microscopic and Histomorphometric Study

Article

Last updated: 07 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Dental Materials
Oral Biology
Oral Medicine, Periodontology and Diagnosis

Abstract

Background:There is an increasing demand for innovative biomaterials and techniques in dental practices to improve regenerative therapies. Researchers have employed guided bone regeneration (GBR) using biologically compatible membranes to repair bone defects. These membranes promote bone healing by ensuring biocompatibility and mechanical stability, and they address issues like edentulous ridges and extraction sockets. This study evaluates the effectiveness of concentrated growth factor membrane (CGF) as a regenerative material for bone defects in rabbits, using histochemical and histomorphometric analysis to assess bone matrix maturation.
Materials and methods: The study included 36 male New Zealand rabbits, each with a one-wall bone defect created near the lower left first molar. The rabbits were divided into two groups: Group I (defects without CGF treatment) and Group II (defects treated with a CGF membrane). Each group was further divided into three subgroups (a, b, and c) based on time intervals of 7, 30, and 45 days. One-way ANOVA was used to analyze and compare the data.
Results: The highest statistically significant mean value was observed in Group II, Subgroup C (48.31 ± 10.36), while the lowest values were seen in both Group I and Group II, Subgroup A, with mean values of 0.00 ± 0.00, indicating no significant difference between these subgroups.
Conclusions: CGF membrane demonstrated great potential for GBR, significantly accelerating bone formation in one-wall defect compared to controls, particularly at 45-days interval. It shows potential for clinical applications improving outcomes for patients undergoing GBR therapies.

DOI

10.21608/edj.2024.328049.3234

Keywords

Concentrated Growth Factor (CGF), Guided Tissue Regenerative Biomaterials, bone regeneration, Light Microscopy and Histomorphometry

Authors

First Name

Mohamed

Last Name

Abdelfattah

MiddleName

Yehia

Affiliation

Lecturer, Oral Biology Department, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt.Lecturer, Oral Biology Department, Faculty of Dentistry, Newgiza University, Giza, Egypt.

Email

mohamed.yehia@ngu.edu.eg

City

Nasr City, Cairo.

Orcid

0000-0002-3370-7980

First Name

Ola

Last Name

Dewedar

MiddleName

-

Affiliation

Lecturer of Oral Biology Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

oladewedar.26@outlook.com

City

-

Orcid

0009-0003-9666-3975

First Name

Mena

Last Name

Abd-Allah

MiddleName

-

Affiliation

Lecturer of Oral Biology, Faculty of Dental Medicine for girls, Al-Azhar University, Cairo, Egypt.

Email

menafathy1980@gmail.com

City

-

Orcid

0009-0003-7588-7320

First Name

Heba

Last Name

Eltayeb

MiddleName

-

Affiliation

Assistant Professor and Head of Dental Biomaterials Department, Faculty of Dental Medicine for Girls, Al- Azhar University, Cairo, Egypt.

Email

h_eltayeb@hotmail.com

City

Egypt

Orcid

0009-0000-8679-9746

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Lecturer, Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Email

lobnaabbdel-aziz.26@azhar.edu.eg

City

-

Orcid

0009-0003-1714-7834

First Name

Shahenda

Last Name

Abdallah

MiddleName

ahmed

Affiliation

Lecturer of Dental Biomaterials , Faculty of Dental Medicine for Girls, Al-Azhar University Cairo, Egypt. Lecturer, Dental Biomaterial, Department of Removable Prosthetics , Faculty Of Dentistry, Misr International University, Cairo, Egypt.

Email

dent_shahy@yahoo.com

City

Egypt

Orcid

0000-0002-3420-4146

First Name

lamis

Last Name

Hussein

MiddleName

-

Affiliation

Associate Professor, at Dental Biomaterials, Department of Removable Prosthetics , Faculty of Dentistry, Misr International University, Cairo, Egypt

Email

lamis.hussein@miuegypt.edu.eg

City

Cairo

Orcid

0000-0001-9001-7559

Volume

71

Article Issue

1

Related Issue

52577

Issue Date

2025-01-01

Receive Date

2024-10-16

Publish Date

2025-01-01

Page Start

317

Page End

326

Print ISSN

0070-9484

Online ISSN

2090-2360

Article File

EDJ_Volume 71_Issue 1_Pages 317-326.pdf

PDF . 3.1MB

Link

https://edj.journals.ekb.eg/article_401318.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401318

Order

401,318

Type

Original Article

Type Code

254

Publication Type

Journal

Publication Title

Egyptian Dental Journal

Publication Link

https://edj.journals.ekb.eg/

MainTitle

Regenerative potential of Concentrated Growth Factor (CGF) Membrane in an Induced Bone Defect Model in Rabbits: A Light Microscopic and Histomorphometric Study

Details

Type

Article

Created At

07 Jan 2025