Objective: Because mechanical plaque control is typically insufficient to fully manage plaque & preserve optimal oral health, using natural plant extracts has been demonstrated to be more effective in managing disorders mediated by dental plaque. Aim: The purpose of this study is to evaluate the clinical efficacy of mouthwashes containing chlorhexidine , pomegranate and a placebo mouthwash in treating gingivitis . Subjects & Methods: This clinical trial included 60 patients having plaque-induced gingivitis, the years old range was among eighteen to forty. Subjects were allocated into three groups: Group A receiving pomegranate peel extract mouthwash & Group B taking chlorhexidine mouthwash. Group C receiving a placebo mouthwash. Clinical indices, including the gingival index (GI), plaque index (PI), & papillary bleeding index (PBI), had been used to assess studied case at baseline (before treatment) & four weeks later. Results: After a four-week follow-up, there was a statistically significant decrease in the mean PI, GI, & PBI scores for all groups. Both pomegranate and chlorhexidine mouthwashes restricted plaque accumulation & gingival inflammation.