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401670

“Tissue and/or Serum Expression levels of miRNA-31 and miRNA-141 as potential diagnostic markers for Colon Cancer in Egyptian Patients”

Article

Last updated: 07 Jan 2025

Subjects

-

Tags

Basic Biomedical Science

Abstract

Cancer colon is the most common cancer of the digestive tract representing the third most common cancer. MiRNAs regulate 30% of human genes. They can act as oncogenes and tumor suppressors. MiRNA-31 expression level is altered in many cancers; it is increased in squamous cell carcinoma, and hepatocellular carcinoma, but significantly decreased in gastric, breast, and prostate cancer. MiRNA-141 is an important member of the miR-200 family regulates different cellular processes, such as proliferation and angiogenesis. The study aimed to determine the tissue and serum expression of miR-31 and miR-141 in Egyptian patients with cancer colon. Fifty subjects were enrolled in this study. They were divided into 2 groups; Group I: 25 newly diagnosed stage II and III primary cancer colon patients, and Group II: 25 healthy controls. Increased expression of miRNA-31 in cancerous tissue more than adjacent noncancerous tissue was observed. Regarding miRNA-141; there was a significant increase in serum miRNA-141 in cancer colon group than the control group. A ROC curve showed that AUC for serum miRNA-141 was 0.869. This suggests the possible use of serum miRNA-141 in diagnosis of CC.

DOI

10.21608/jmalexu.2024.340947.1038

Keywords

MiRNA-31, MiRNA-141, Cancer Colon

Authors

First Name

Noha

Last Name

Kandil

MiddleName

Said

Affiliation

Chemical pathology reaction

Email

nohakandil80@gmail.com

City

-

Orcid

-

First Name

mohamed

Last Name

abdelrahman

MiddleName

-

Affiliation

military hospital

Email

mohamed.abdelrahman@yahoo.com

City

-

Orcid

-

First Name

mohamed

Last Name

kamel

MiddleName

-

Affiliation

mri

Email

mohamed.samir@yahoo.com

City

-

Orcid

-

First Name

mohamed

Last Name

shamsya

MiddleName

-

Affiliation

mri

Email

mohamedmohammed.abdoushamseya@gmail.com

City

-

Orcid

-

First Name

Mona

Last Name

Abdel Ghany Haiba

MiddleName

-

Affiliation

mri

Email

monahaiba@yahoo.com

City

-

Orcid

-

First Name

Maher

Last Name

Kamel

MiddleName

A

Affiliation

Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt

Email

maher.kamel@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-6791-9850

First Name

thanaa

Last Name

moghazy

MiddleName

-

Affiliation

mri

Email

thanaa.moghazy@gmail.com

City

-

Orcid

-

Volume

45

Article Issue

4

Related Issue

52539

Issue Date

2024-12-01

Receive Date

2024-12-10

Publish Date

2024-12-01

Page Start

43

Page End

52

Print ISSN

1110-0133

Online ISSN

2682-2547

Link

https://jmalexu.journals.ekb.eg/article_401670.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401670

Order

5

Type

Original Article

Type Code

1,490

Publication Type

Journal

Publication Title

Journal of the Medical Research Institute

Publication Link

https://jmalexu.journals.ekb.eg/

MainTitle

“Tissue and/or Serum Expression levels of miRNA-31 and miRNA-141 as potential diagnostic markers for Colon Cancer in Egyptian Patients”

Details

Type

Article

Created At

07 Jan 2025