This investigation was to evaluate the biological effects of red grape and beetroot juice nutrients on glucose level, renal function, liver enzymes, and immune status using rats as an animal model. Results revealed that rat diets supplemented with 5% red grape juice and 10% beetroot juice significantly   P < 0.05 decreased the serum glucose levels from 150.3 mg/dL to 85.5 mg/dL. However, we recorded a significant decrease in serum urea, creatinine, and uric acid concentrations as compared to the positive control group. Rats supplemented with 10% food compositions of both red grape and  beetroot juice had a significant P < 0.05 decrease in both ALT and AST from 85.3 U/L and 155.3 U/L to 25.3 U/L and 59.6 U/L, respectively. On the other hand, (5% red grape/beetroot juice), increased both cellular immunity phagocytes and lymphocyte cells by (76,1.31 and 90,1.78 ) respectively, without any histopathological change in the kidney suggesting that the selected experimental diet is safe.