Background: Nurses' compassion is an important factor in patient-centered nursing. Furthermore, understanding the patients' perspective and providing necessary nursing care is the goal of patient-centered nursing. Aim: This study aimed to explore the relationship between nurses' compassion and patient-centered care competency at the Egyptian Health Care Authority hospitals in Port Said governorate. Subjects and Method: Design: Descriptive correlational design was used. Setting: the study conducted at the Egyptian Health Care Authority hospitals in Port Said governorate namely: El-Salam Port Said Hospital, El-Zohour Hospital, El-Nasr Hospital, Ophthalmology Hospital, Women's Health Hospital, and El-Haya Port-Fouad Hospital. Subjects: included 301 staff nurses working in the study settings. Tools: Three tools used for data collection consisted of; Personal and Job-Related Data Questionnaire, Nurses' Compassion Competence Scale, Patient-Centred Care Competency Scale. The Results: 98% of the studied nurses showed high level of compassion, and 2% of them showed moderate level. While, 95.7% of them had high level of patient-centered care competency, and 4.3% of them had moderate level. Conclusion: There was statistically significant correlation between the studied nurses' compassion and their total patient-centered competency. Recommendations: Compassionate care should be introduced as a core component of patient-centered care affect patient outcomes. Also, encourage nurses to report factors affect delivering of compassionate care.