Staphylococcus aureus is the main cause of poultry Staphylococcosis, it is widely spread in the poultry farm environment, including the air, water, sewage, and dust, which usually contain it and they are significant nosocomial pathogens and members of the opportunistic bacteria. Additionally, Staphylococcal food poisoning is considered one of the most prevalent food-borne illnesses in the world. It is caused by enterotoxigenic strains of S. aureus in food. Broiler chickens may suffer from S. aureus infection and its enterotoxins resulting in a major public health hazard and economic losses due to decreased weight gain, mortality, and increased condemnation, so this review aims to summarize and address current knowledge about diseases caused by S. aureus in broiler chickens together with understanding the significant virulence and resistance factors which may help in control its occurrence in animal farms and to understand food poising in human