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402233

The Diagnostic Reliability of a Novel 13-Carbon Urea Breath Test in the Identification of an Active Pulmonary Tuberculosis

Article

Last updated: 07 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: The accuracy of diagnostic tests in intervention studies for eradicating Mycobacterium tuberculosis is critical. Objective: This study aims to determine the threshold value for the innovative 13-carbon urea breath test in the diagnosis of pulmonary tuberculosis. Methodology: We conducted a prospective case-control research study to evaluate the accuracy of administering a dosage of 75 mg of C13-urea to a cohort of 200 volunteers, which included 100 individuals in excellent health and 100 individuals suffering from pulmonary tuberculosis. We used a jet nebulizer to deliver the C13-urea and a double-beam infrared spectrophotometer to analyze the exhaled breath. Results: The area under the curve (AUC) was ranging between 0.988 and 1. The test's sensitivity ranged from 98% to 100%, while its specificity ranged from 40% to 100%. We determined the ideal threshold to be 0.288, ensuring 100% sensitivity and specificity. Conclusion: The 13C urea breath test exhibited an extremely high degree of sensitivity in detecting pulmonary tuberculosis. This test offers the possibility to diagnose Mycobacterium tuberculosis in clinical practice with good sensitivity, low cost, and rapid results.

DOI

10.21608/ejmm.2025.342394.1396

Keywords

novelty, Carbon 13, tuberculosis, sensitivity, specificity

Authors

First Name

Mohammed

Last Name

Alfahdawi

MiddleName

A.

Affiliation

Medical Laboratories Techniques Department, College of Health and Medical Technology, University of Al Maarif, Al Anbar, 31001, Iraq

Email

mohammed.a.h@uoa.edu.iq

City

-

Orcid

-

First Name

Yasir.

Last Name

Abdulateef

MiddleName

M.

Affiliation

Microbiology Department, College of Medicine, University of Anbar, Iraq

Email

dr.yasserjanai@uoanbar.edu.iq

City

Ramadi

Orcid

-

First Name

Haitham

Last Name

Eyada

MiddleName

N.

Affiliation

Internal Medicine and Infectious Diseases Department, University of Anbar, College of Medicine, Anbar, Iraq

Email

med.haitham.numan@uoanbar.edu.iq

City

Ramadi

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2024-12-07

Publish Date

2025-04-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_402233.html

Detail API

http://journals.ekb.eg?_action=service&article_code=402233

Order

402,233

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

The Diagnostic Reliability of a Novel 13-Carbon Urea Breath Test in the Identification of an Active Pulmonary Tuberculosis

Details

Type

Article

Created At

07 Jan 2025