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401304

Renoprotective Effect of Maresin-1 in Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats: Targeting TLR4/NF-kB Pathway

Article

Last updated: 07 Jan 2025

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Subjects

-

Tags

Renal Physiology

Abstract

Background: Essential hypertension causes the kidney illness known as hypertensive nephropathy, which frequently results in both structural and functional renal impairment. A lipid mediator that is naturally produced from omega-3 fatty acids, maresin-1 (MaR1), may be able to considerably lessen the symptoms of a number of inflammatory illnesses.
Objective: to demonstrate the underlying mechanisms and renoprotective impact of MaR1 in rats with deoxycorticosterone acetate-salt-induced hypertension.
Material & Methods: Thirty Wister albino male rats divided into control, DOCA, DOCA+MaR1 groups. After 8 weeks rats were subjected to ABP, renal blood flow velocity (RBFV) and renal artery resistance (RAR) measurement and serum levels of urea, creatinine in addition to creatinine clearance, urinary albumin, renal MDA, SOD, TNF-α, IL-6, renal genes expression of TLR4 and NF κB were assessed. Renal tissue was evaluated histopathologically and immunohistochemically.
Results: The DOCA group's measured SBP, DBP, MABP, RAR, serum levels of urea, creatinine, renal MDA, renal TNF-α, renal IL-6, and renal genes TLR4 and NF-kB were all dramatically elevated than those of the control group, but their RBFV, renal SOD, and creatinine clearance values were significantly lower. MaR1 significantly enhanced the alterations brought about by DOCA.
Conclusion: MaR1 alleviated DOCA induced hypertensive nephropathy by anti-oxidant, anti-inflammatory, anti-apoptotic mechanisms and by down-regulation of TLR4 and NF κB renal genes expression.
Key words: Caspase-3, DOCA, Hypertension, Maresin-1, NF κB, TLR4

DOI

10.21608/besps.2024.341840.1191

Keywords

caspase3, DOCA, Hypertension, Maresin1

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Ahmed

Last Name

Gaafar

MiddleName

Mohamed

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

amrahmad2004@gmail.com

City

Shebin El-Kom

Orcid

-

First Name

Mohamed

Last Name

Amer

MiddleName

Shebl

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

fbsmsaa@gmail.com

City

-

Orcid

-

First Name

Amany

Last Name

Wahb

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Helwan University, Egypt.

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

Amany

Last Name

Elfakhrany

MiddleName

-

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

amany.elfakhrany@med.menofia.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Safwat

MiddleName

-

Affiliation

Human Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Ain Shams, Cairo, Egypt. Anatomy Department, IbnSina National College for Medical Studies, Jeddah

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Heba

Last Name

Sherif

MiddleName

-

Affiliation

Internal Medicine department Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Alaa

Last Name

Bahbah

MiddleName

M

Affiliation

Pathology department Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

hashema877@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Bayomi

MiddleName

-

Affiliation

Zoology Department - Faculty of Science, Menoufia University, Menoufia, Egypt.

Email

asmaabolty@yahoo.com

City

-

Orcid

-

First Name

Samar

Last Name

Hussein

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.

Email

soso_egy@yahoo.com

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

50789

Issue Date

2025-01-01

Receive Date

2024-12-05

Publish Date

2025-01-01

Page Start

123

Page End

137

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 45_Issue 1_Pages 123-137.pdf

PDF . 1.1MB

Link

https://besps.journals.ekb.eg/article_401304.html

Detail API

http://journals.ekb.eg?_action=service&article_code=401304

Order

401,304

Type

Review Article

Type Code

574

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Renoprotective Effect of Maresin-1 in Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats: Targeting TLR4/NF-kB Pathway

Details

Type

Article

Created At

07 Jan 2025