Background: Following the recommended fluid regimens is essential to the effectiveness of dialysis since it affects the patient's outcomes and sense of self-efficacy. Aim of the study: Evaluates the fluid adherence and self-efficacy in patients undergoing hemodialysis after receiving the nursing instructions. Research design: To achieve the aim, a Quazi-experimental research design was used.. Setting: This study was conducted at the Hemodialysis Unit, during the dialysis session, at Nephrology and Urology Hospital at Minia University, Minia City, Egypt. Subjects: A purposive sample is constituted (90) patients participated in the study. Tools: For this study, three tools were created and utilized to gather data., First Tool: Interview Questionnaire Sheet includes two parts 1st Part: Personal data. 2nd Part: Medical Data of the patient. Second Tool: Fluid Adherence assessment sheet, which include three parts: 1st part: Fluid Adherence questionnaire, 2nd Part: Pitting Edema Scale. Third tool: Self-efficacy questionnaire. Results: After one and two months, the patient's response to fluid adherence improved in a highly statistically significant manner. Patients self efficacy was statisticay imrpved after the one  month and two months of fluid adherence and shows positive correlation. Recommendations:  The hospital should pay more attention to and closely monitor patient compliance with therapeutic hydration restriction, and a large sample size should be used for study replication.  Conclusion: The current study documented the improvement in fluid adherence among the studied hemodialysis patients after implementing the nursing intervention which approves our study hypothesis.