Background: Family communication patterns have a key role in shaping a child's development, life skills, and emotional security. Aim of the study: This study aimed to assess the relation between family communication patterns, life skills, and emotional security among preschool children. Subjects and Methods: Research design: A cross-sectional descriptive research design was used. Setting: The study was conducted in four governmental nursery schools in Zagazig City, Egypt. Subject: A multistage cluster sampling technique on 220 preschool children. Tools of data collection: The data were collected using an interview questionnaire with three standardized scales, namely the family communication pattern scale, the child life skills scale, and the emotional security scale. Results: Children's mean age was 5.30; 53.6% were males. Only 35.5% of the families had high family communication patterns, 57.7% of the children had high life skills, and 84.5% had high total emotional security. In multivariate analysis, the family communication patterns and emotional security were positive predictors of life skills scores. Conclusion: The results of the study lead to the conclusion that the family communication patterns used by preschool families are suboptimal, with very low use of the consensual pattern. Life skills are better, although still low in about half of the preschool children. Conversely, emotional security is mostly high except for the mood state. Recommendations: The study recommended that health education programs for parents of preschool children focus on improving family communication patterns and training programs for parents and their children that focus on improving life skills and emotional security, and further studies are proposed to investigate the factors affecting family communication patterns, life skills, and emotional security of preschool children for generalization of study results.