Background: The importance of organizations recognizing toxic leadership and understanding its substantial effects on followers and organizational culture. It advocates for tactics to address toxic leadership. Aim of the study: The present study was conducted to assess the relationship between toxic leadership practices and nurses' perceived turnover intention. Subjects and Methods: Research Design: A descriptive correlational research design was used. Setting: This study was conducted at Zagazig University Hospitals, Egypt. Subject: A stratified random sample (n=375) of staff nurses. Tools of data collection: Data were collected by using two tools, namely, the toxic leadership scale, composed of four parts, and the turnover intention scale, composed of three parts. Results: Analysis revealed that more than half of the studied nurses had a high perception level of toxic leadership, as well as nearly half of the studied sample having a low perception of turnover intention. Conclusion: There was a statistically significant positive correlation between staff nurses perception of toxic leadership and turnover intention. Recommendations: The study recommended that hospital administrators could conduct training programs for supervisors to improve their leadership skills and behavior, developing programs to refine the skills for the followers to use strategies and coping techniques to deal with toxic leaders.