Background: Despite the progress in the management of sepsis, the shortcomings of routine investigations necessitated the search for new biomarkers to be used as early predictors for sepsis outcomes.
Objectives: To define the relations of progress to septic shock (SS) and mortality rate (MR) among sepsis patients with serum omentin-1 levels estimated at admission to the surgical ICU.
Patients and methods: 160 sepsis patients were evaluated using the quick sepsis-related Organ Failure Assessment (q-SOFA) score and SOFA score at admission (T0-time) and 24 h thereafter (T24) to calculate delta-SOFA (∆SOFA). The frequency of SS and the 28-d MR were determined. The study outcome is defining the relation of lab parameters estimated at T0-time and ∆SOFA for the incidence of SS and MR.
Results: SS was diagnosed in 53 patients, and the total MR was 23.125%. The incidence of the development of SS and ICU mortality was positively correlated with ∆SOFA but was negatively correlated with at-admission serum omentin-1 levels. Serum omentin-1 levels showed a negative significant correlation with ∆SOFA (P=0.008) and serum levels of C-reactive protein (P=0.030), interleukin-6 (P=0.004), and tumor necrosis factor-α (P=0.014).
Conclusion: The calculated ∆SOFA at 24 h after ICU admission is preferable to SOFA scoring to determine the change in evaluated parameters through 24 h. Combined high ∆SOFA and at-admission low serum omentin-1 were significantly correlated with the incidence of SS and mortality at the surgical ICU and might be used as early identifiers for patients vulnerable to bad outcomes.