Antiphospholipid syndrome is an autoantibody-mediated acquired thrombophilia which is characterized by recurrent arterial or venous thrombosis and/or pregnancy morbidity. Presence of dengue infection along with this, can induce its catastrophic form which involves coagulopathic thrombosis by immunogenesis. Catastrophic variant can cause multiorgan dysfunction and can also lead to morbidity and mortality in APLA patients. So, focusing on APLA syndrome with prevention of its catastrophic form due to presence of active viral infection, hereby, we discuss a case report of the anaesthetic management of 35 year-old, 55-kg female, G6P2L1A3 with previous one lscs with 36 weeks of gestation posted for an emergency caesarean section. Further, measures that are necessary for prevention of catastrophic variant of antiphopholipid syndrome are discussed in this review. Also in patients with a history of antiphospholipid syndrome with active infection, there is limited literature available with no proper set of guidelines for safe conduct of anaesthesia .