Background: Effective nursing practice scheme for stroke patients is a proactive procedure that starts with hospitalization care and ends with the patient returning to the community. Its goal is to help the patients regain their functional independence and resume an active and productive lifestyle. Aim: to investigate the effect of nursing practice scheme on knowledge and remedial compliance among patients with stroke. Research design: A quasi- Experimental (pre and posttest) was utilized in this study. Setting: It was conducted in the Neurology department at Sohag University Hospital, Sample: A sample of 84 patients who confirmed diagnosis of stroke, with age 35-65 years old. Tools: Two tools were used: Tool (I): Structured Interviewing questionnaire for patients, Tool (II): Compliance assessment questionnaire: (pre/ post).Results: less than three quarters of the studied patients had low knowledge level at pre-nursing practice scheme that decreased to be 8.3% at post nursing scheme phase. While, 10.7% of them had good knowledge level that increased to be 65.5% at post nursing scheme phase. 19% of them had medium compliance with medication level at preprogram that increased to be 61.9% of them at post nursing scheme phase. Conclusion: There was statistical significant positive correlation between the studied patient's knowledge, compliance with medication and compliance with exercise at pre and post nursing scheme at (P <0.05). Recommendation: replication of this study on a larger probability sample and evaluating its effect on health outcomes among stroke patients.