Indomethacin (IND) is a non-steroidal anti-inflammatory drug (NSAID) used widely in the pharmaceutical industry. Although it was used as an anti-inflammatory, gastrointestinal bleeding and ulceration were reported as the main untoward effects of IND. Essential oils are prominent worldwide in traditional and folk medicine due to their healing properties and therapeutic effects. This study was carried out to investigate the potential protective effect of using some essential oils, such as Curcumin, Thyme, and Chamomile, against ulcer induced by indomethacin. Thirty-five male albino rats were classified into a standard control group and five IND-induced gastric ulcer groups, divided into non-treated control (+ve) and treated groups with Curcumin oil, Thyme oil, and Chamomile oil groups for one-month. The results revealed that the treatment with these oils could protect from IND-induced gastric ulceration. The mechanism of its gastro-protective activity may be attributed to a significant reduction in serum interleukin 6 (IL6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA) and High-Density Lipoprotein (HDL-C) along with significant elevation in serum total antioxidant capacity (TAC), reduced glutathione (GSH) and hematological parameters compared with ulcerated control (+ve) group. The histopathological examination confirms these acquired results. Conclusion: The protection provided with the treatment of Curcumin, Thyme, and Chamomile oils possesses anti-ulcer potential due to their antioxidant and anti-inflammatory properties.