The purpose of this study was to examine how caper root affected fatty liver in rats. There were 36 male albino rats utilized in this work, and each one weighed 150 ± 5 g. The first group (n = 6) consumed the control diet (-ve). The second set of animals (n = 6) were given a high-fat diet along with fructose to cause fatty liver. Fructose (10, 15, 20 %) from caper root was added to the high-fat diets of groups (3-6). Weight gain, food intake, and the feed effectiveness ratio were all improved across the board for the fatty liver groups that were given 10%, 15%, 20% caper root Extract. Animals given the high-fat diets and the caper root treatments had significantly lower body weights than those given the positive-control diets (P≤ 0.05). Statistical analysis, however, showed that the 20% caper root rat group was not substantially distinct from the control group (P ≥ 0.05). The data revealed, in comparison to the positive control group, that the treated groups' levels of AST, ALT, ALP enzymes, creatinine, blood urea, and uric acid were significantly lower. When compared to the control (+ve) group, the findings indicated that high-fat diet rat groups given Caper at concentrations of 10, 15, 20% caused significant reductions (P ≤ 0.05) in the values of serum total cholesterol, TG, LDL-cholesterol, VLDL, and HDL-cholesterol while showing a mostly significant increase (P ≤ 0.05) in the values of serum HDL-cholesterol. Malondialdehyde was reduced and serum glutathione levels were increased due to caper. Because of its ability to reduce cholesterol and improve liver and kidney function. The study concluded that caper root should be incorporated into diets to combat hypercholesterolemia.