A reduction in renal function has a major effect on metabolism and nutritional status. It has been discovered that several plants have antioxidant effects and can defend against experimental kidney toxicity. This study examined the effects of powdered 5% horsetail, 5% hollyhock and 5% mixtures of it on nephrotoxic rats. In this experiment was used 25 adult male albino rats weighing 150±10g. The rats were divided into 5 groups. Each group contains 5 rats. Gentamicin was administered intravenously to the other groups once daily for 7days while one was kept as the (-ve) group. The following data were determined glucose level, serum liver enzymes (AST, ALT, and ALP), markers of kidney functions (urea, creatinine, uric acid), lipid profile (triglycerides, total cholesterol, VIDL-c, HDL-c, LDL-c), serum electrolyte (sodium, chloride and calcium) and histopathology of the kidney. Also, it was was determined phenolic compounds of horsetail & hollyhock. The results of HPLC showed that the horsetail contained higher bioactive compounds than hollyhock leaves. According to the results, rats' kidney, liver and lipid profiles were all enhanced by the combination of horsetail and hollyhock leaves powder. The best results were shown with the 5% mixture, which is advised for use as a beverage drink to improve kidney functioning. In conclusion: In the treatment of rats with renal failure, Horsetail and hollyhock leaves can be considered as potential therapeutic feeding programs.