The research aims to design a sports program using aerobic exercise and study its effect on the rate of secretion of the thyroid gland and its role in weight loss. The researchers used the experimental approach with an experimental design for one group using (pre-post) measurement for it. The researchers selected the research sample intentionally from the research community and it amounted to ( 8) Patients with insulin resistance who attend the Beni Mazar City Youth Center affiliated with the Minya Youth Administration. In light of the results of the research to achieve its goal, which came through verifying the hypotheses that were set for this purpose, the researcher concluded that the sports program using aerobic exercises is positive and its effect on the rate of glandular secretion. The thyroid and its role in weight loss. This was shown by the presence of statistically significant differences between the average ranks of the pre- and post-measurements for the group under study in the level of thyroid hormones “TSH - T3 - T4" and the level of blood sugar and body weight in favor of the post-measurement.