Purpose – This research examined the role of Organizational Agility (OG) dimensions (Compatibility, Implementation, Leadership capabilities, and Roles and Responsibilities) to achieve the Institutional Excellence (IE) through the mediating effect of Organizational Competence (OC) in private Egyptian universities. 
Design/methodology/approach – This research relies on the descriptive analytical approach, A total of (318) valid responses were collected for data analysis.
Findings – The findings revealed that there is a positive relationship between organizational agility and institutional excellence in Egyptian private universities, and there is a significant effect of the organizational agility variable on the institutional excellence variable. There is a direct relationship between organizational competence and institutional excellence in Egyptian private universities, and there is a significant effect of the organizational competence variable on the institutional excellence variable.
Practical implications – This research offered several managerial recommendations. By considering Organizational Competence (OC) as a tool, adopting more strategies and methods that support organizational excellence, which ensures providing a positive atmosphere and organizational culture that motivates outstanding performance.