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365691

EVALUATION OF BONE HEALING BY MESENCHYMAL STEM CELLS IN RABBITS (AN EXPERIMENTAL STUDY)

Article

Last updated: 30 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Oral and maxillofacial surgery

Abstract

Background: Large bone defects are considered a massive challenge in the field of oral and maxillofacial surgery. Cell Therapy using bone marrow-derived mesenchymal stem cells (BM-MSCs), as an alternative technique, has effective potential for bone regeneration.
Aim of the study: To compare histologically the bone healing rate of critical size defects in rabbit tibia using mesenchymal stem cells versus untreated defects.
Materials and Methods: Critical-sized defects were prepared on the tibia of rabbits. Experimental groups were divided into 2 groups: (a) Control group; untreated rabbits left for spontaneous healing, (b) collagen sponge with MSCs treated group. Sacrificing of rabbits was done at 2 and 6-week intervals.
Results :Bone defects treated with BM-MSCs showed a marked increase in the healing rate compared to the control group. Histological examination showed immature bone trabeculae lined with plump active osteoblasts with minimal amount of newly formed blood vessels and almost no inflammatory cell infiltration at the 2-week interval. Furthermore, at the 6-weeks interval the defects were almost healed with mature thickened dense bone trabeculae lined by fattened osteoblasts with no inflammatory infiltration.
Conclusion: BM-MSCs are a promissing tool for bone regeneration.

DOI

10.21608/adjalexu.2024.246336.1431

Keywords

Mesenchymal Stem Cells, bone healing, Rabbits, critical size defect

Authors

First Name

Fadi

Last Name

Salib

MiddleName

Fouad

Affiliation

Oral and Maxillofacial Surgery, Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Email

fadyfouad1993@gmail.com

City

Alexandria

Orcid

-

First Name

Magda

Last Name

Saleh

MiddleName

Mohamed

Affiliation

oral and Maxillofacial surgery, Faculty of Dentistry Alexandria University

Email

magdasaleh182@gmail.com

City

Alexandria

Orcid

-

First Name

Radwa

Last Name

Mehanna

MiddleName

-

Affiliation

Department of Medical Physiology, Faculty of Medicine, Alexandria University, Egypt Center of Excellence for Research in Regenerative Medicine and Applications (CERMA), Faculty of Medicine, Alexandria University, Alexandria, Egypt

Email

radwa.mehanna@alexmed.edu.eg

City

Alexandria

Orcid

-

First Name

Marwa

Last Name

Essawy

MiddleName

Morsy

Affiliation

Oral Pathology Department, Faculty of Dentistry, Alexandria University, Egypt. Center of Excellence for Research in Regenerative Medicine and Applications (CERRMA), Faculty of Medicine, Alexandria University, Egypt

Email

marwa.morsy@alexu.edu.eg

City

Alexandria

Orcid

0000-0002-4781-4293

First Name

Lydia

Last Name

Melek

MiddleName

Nabil

Affiliation

Associate Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Egypt

Email

lydia.nabil@gmail.com

City

Alexandria

Orcid

-

Related Issue

-2

Receive Date

2023-11-21

Publish Date

2024-07-08

Print ISSN

1110-015X

Online ISSN

2536-9156

Article File

ADJALEXU3656911720386000.pdf

PDF . 519.3kB

Link

https://adjalexu.journals.ekb.eg/article_365691.html

Detail API

https://adjalexu.journals.ekb.eg/service?article_code=365691

Order

15

Type

Original Article

Type Code

1,057

Publication Type

Journal

Publication Title

Alexandria Dental Journal

Publication Link

https://adjalexu.journals.ekb.eg/

MainTitle

EVALUATION OF BONE HEALING BY MESENCHYMAL STEM CELLS IN RABBITS (AN EXPERIMENTAL STUDY)

Details

Type

Article

Created At

30 Dec 2024