Background: Gingival Recession is an apical migration of the marginal gingiva concerning the Cemento-Enamel Junction. Different techniques are used to manage GR, including Platelet-Rich Fibrin (PRF). The latter has several advantages: it does not require a second surgical site intervention, is completely autogenous, and contains numerous growth factors. However, contamination of PRF may happen from plastic or glass tubes. Therefore, Titanium prepared Platelet-Rich Fibrin (T-PRF) can be used to overcome this disadvantage.
Study objective: To assess the effect of using the T-PRF with Coronally Advanced Flap (CAF) in the management of Cairo gingival recession type-2 (RT2) and compare it to the use of Sub-Epithelial Connective Tissue Graft (SECTG).
Materials and methods: This randomized controlled clinical trial was conducted on 44 sites with Cairo RT2. After performing phase I therapy, sites were divided into two groups: Test group, included 22 defects managed by CAF in conjunction with T-PRF. Control group: included 22 defects managed by CAF in conjunction with SECTG. Clinical assessment was done immediately before surgery, at baseline, then three and six months postoperatively.
Results: It showed that both SECTG and T-PRF with CAF could improve the PD, CAL, and RD from baseline to six months follow up, but SECTG + CAF showed superior results.
Conclusion: Within the limitations of this study, the results showed the superiority of autogenous CTG in root coverage (RC). However, T-PRF was a safe and effective choice for partial RC in RT2. However, it doesn't require a second surgical site intervention.