Introduction: Titanium prepared platelet rich fibrin (T-PRF) has been applied as an alternative to the traditional bone graft in sinus lifting approach.
Objectives: This trial aimed to evaluate the effect of the use of T-PRF alone on bone formation process as applied in maxillary sinus floor elevation in comparison to traditional T-PRF/bone graft combination as indicated by implant stability as primary objective.
Materials and Methods : This clinical trial included 18 patients seeking implant placement in upper posterior maxilla compromised with maxillary sinus pneumatization. All the patients underwent sinus lifting procedure through which a combination of xenograft and T-PRF was used in the control group whereas; T-PRF alone was applied in the test group. Delayed implant placement was applied. The two groups were compared in clinical, radiographic and histological parameters.
Results: Clinical results revealed that there was no significant difference between T-PRF/ xenograft group and T-PRF group in terms of primary stability (p value=0.811). Radiologically, T-PRF/xenograft showed superior outcomes than T-PRF group in total bone height gain and pre-implant bone density gain (p value=0.001, 0.002 respectively). Histomorphometric results indicated that the difference between the control and test groups was not significant.
Conclusions: T-PRF alone can be used as an effective grafting material in two stage maxillary sinus augmentation as proven by implant stability as the primary objective. Acceleration of bone formation process can be achieved by means of T-PRF whether alone or in combination of xenograft.