Aim: to investigate the effect of Vascular endothelial growth factor(VEGF) with and without Aloe vera in the management of induced critical sized class II furcation defects in dogs using guided tissue regeneration (GTR) approach.
Materials and Methods: thirty two critical-sized furcation defects on the buccal surface of mandibular third and fourth premolars were surgically created in eight dogs and divided into two groups. Group I; Sixteen defects were managed using VEGF, aloe vera, 𝛽- tricalcium phosphate bone graft (𝛽- TCP) and collagen membrane. Group II; Sixteen defects were managed using VEGF, 𝛽- TCP and collagen membrane. Histological and histomorphometric analysis of the newly formed interradicular bone height and its percentage were performed after one and two months.
Result: histological examination revealed greater regenerative features in the defects in the second observation period than in the first one. The difference were observed in the forming alveolar bone, cementum thickness, PDL density and fiber orientation. This histological observation were confirmed by the obtained values of the morphometric measurements of the two tested variants
Conclusion: VEGF and Aloe vera showed better results than VEGF alone in bone regeneration, cementum thickness, PDL density and fiber orientation. Aloe vera with VEGF have expected to be well established in the field of guided tissue regeneration.