Molar–incisor–hypomineralization (MIH) is a developmental defect of enamel dental tissue caused by the disturbances in the maturation stage of amelogenesis. It usually affects the permanent first molars and incisors. In children, MIH condition clinically appears as the demarcated discolored hypomineralized defects of affected teeth, post‐eruptive breakdown (PEB) of affected enamel, dentine exposure, hypersensitivity, increased susceptibility to dental caries and behavioral management challenges owing to dental anxiety/fear and dental esthetic concerns. Developing skeletal Class III malocclusion is one of the most challenging problems for orthodontists. Whether to start early treatment or wait for growth to be over is still an ongoing debate. This case report describes the comprehensive dental management of MIH with a class III malocclusion in a 7‐year‐old female pediatric patient. The purpose of the current case report is to discuss the treatment of MIH-affected teeth in a pediatric patient, with emphasis on the management of first molars with immature apexes, besides hypomineralization defects and posteruptive breakdown. It also highlights the early orthodontic treatment approach for class III malocclusion.