Background: Sustainability in nursing is essential for promoting long-term environmental and public health, ensuring safe and healthy future for current and upcoming generations. Nurse managers are key to implement sustainable practices within healthcare institutions, and make their understanding of the Sustainable Development Goals vital to fostering a culture of sustainability. Aim: To develop, implement, and evaluate an educational program about the Sustainable Development Goals for nurse managers. Study design: A quasi-experimental design was employed in this study. Setting: The study was conducted at Al-Azhar University Hospital and Assiut University Hospitals. Study sample: Convenience sample included all nurse managers at Al-Azhar University Hospital (n=54) and Assiut University Hospitals (n=218). Data were collected with a questionnaire that consists of two parts, one part related to personal characteristics as department, hospital name, age, years of experience, gender, educational qualification, and previous training) second part includes knowledge of Sustainable Development Goals scale: An open-ended questionnaire consisted of seven questions to assess understanding of the Sustainable Development Goals in nursing. Results: Prior to the educational program, nurse managers in both groups exhibited low levels of knowledge about Sustainable Development Goals. Post-program assessment revealed significant improvement in their knowledge, indicating the effectiveness of the educational intervention. Recommendations: Ongoing evaluation and follow-up assessment are recommended to monitor the retention and application of Sustainable Development Goals knowledge. Further research should investigate the long-term effects of Sustainable Development Goals education on sustainable healthcare practices and leadership.