This study investigates the psychological resilience and its relation to spiritual intelligence among mothers of individuals with autism in Bethlehem Governorate. The aim is to explore how these dimensions correlate with various demographic variables including the mother's age, education level, and the severity of the child's autism. Methods: Utilizing a descriptive correlational design, the study surveyed 63 mothers using the Psychological Resilience Scale and a Spiritual Intelligence Scale. Results: Results indicated medium levels of spiritual intelligence and high levels of psychological resilience among the participants. No significant differences were found in psychological resilience or spiritual intelligence based on the mother's age, educational level, or the autism spectrum severity of their children. Additionally, a significant positive correlation was observed between the levels of psychological resilience and spiritual intelligence. Conclusions: The findings underscore the importance of psychological resilience and spiritual intelligence in managing the challenges faced by mothers of autistic children. The lack of significant differences across demographic variables suggests that these attributes are universally vital across this population group. The strong correlation between psychological resilience and spiritual intelligence highlights the potential benefits of interventions that foster these qualities to support maternal well-being.