This paper investigates the impact of entrepreneurial orientation (EO) on the performance of Egyptian Universities mediated by knowledge management processes (KMP) and strategic agility (SA).A self-reported survey was distributed to faculty members in 19 non-public Egyptian Universities, 500 surveys were distributed and 435 were collected. Data was analyzed using SPSS/AMOS utilizing simple linear regression analyses, multiple regression analyses, structured equation modeling and path analysis.  Empirical investigation revealed varying impacts of multiple research constituents. Results indicated significant positive impacts of EO dimensions on firm performance (FP), KMP and SA, confirmed KMP mediation EO-FP and partial mediation of SA. FP was significantly affected by KMP dimension (except conversion) and SA dimensions (except strategic sensitivity). Moreover, results concluded a significantly positive KMP-SA association.