This study assesses the quality and suitability of irrigation water in Qalabasho-Zaian area (northern Dakahlia Governorate). Water samples from 23 sites were collected from irrigation and drainage networks across the study domain. Different chemical parameters of the sampled water were analyzed, including pH, electrical conductivity, major ions (Ca, Mg, K, and Na), and sodium adsorption ratio (SAR). Results indicate that, for the majority of the analyzed parameters, the irrigation and drainage networks were mostly beyond the safe limits of irrigation use. Specifically, we noted high salinity levels for irrigation water, as well as for potentially toxic elements such as Cd, Cr, Cu, Fe, Mn, Al, Se, V, Ni, Zn, As, Hg, Mg, Ca, Sr, In, Ba, and Ag. This high level of pollution is linked mainly to the location of the study domain at the end of a network of irrigation and drainage channels, combined with the proximity of the study area to a local industrial zone (Gamasa) and effluents discharge from industrial plants. Recalling the national policies that aim to maximize the use of the recycled of irrigation water, the results of this study can inform policy decisions at the local and regional levels regarding water quality standards, agricultural practices, and land use planning. This can help policymakers develop regulations and guidelines to protect water resources, promote sustainable agriculture, and mitigate potential risks to human health and the environment.