Due to the importance of improving salt-affected soils in Egypt's agricultural security policy, a field experiment was conducted in the winter season of 2021/2022 at Kom Abou-Khallad village, Nasser City, Beni-Suef Governorate, Egypt, aiming to determine the impact of various amendments with two-tillage systems on certain properties of salt-affected soil, as well as the growth and productivity of alfalfa plants. Different amelioration techniques were applied using soil conditioners (natural gypsum, modified cement dust, phosphogypsum, and filter mud) that were carried out under two tillage systems, namely, shallow and deep (subsoil). The results show that subsoil tillage decreased bulk density, penetration resistance, pH, EC, and ESP and increased total porosity, hydraulic conductivity, available water and soil organic matter as well as increased the fresh and dry yield of alfalfa plants and protein (%), N, P and K uptake in alfalfa shoots. Treated alfalfa plants cultivated in salt-affected soil with soil conditioners, especially filter mud (FM1) at a rate of 100% G.R resulted in a decreased hazardous effect of salinity by improving soil properties, which consequently increased its productivity.